Bat severe acute respiratory syndrome-like coronavirus ORF3b homologues display different interferon antagonist activities.
Identifieur interne : 001D60 ( Main/Exploration ); précédent : 001D59; suivant : 001D61Bat severe acute respiratory syndrome-like coronavirus ORF3b homologues display different interferon antagonist activities.
Auteurs : Peng Zhou [République populaire de Chine] ; Hongxia Li [République populaire de Chine] ; Hanzhong Wang [République populaire de Chine] ; Lin-Fa Wang [Australie] ; Zhengli Shi [République populaire de Chine]Source :
- The Journal of general virology [ 1465-2099 ] ; 2012.
Descripteurs français
- KwdFr :
- Animaux, Chiroptera (virologie), Données de séquences moléculaires, Facteur-3 de régulation d'interféron (métabolisme), Facteurs de virulence (génétique), Facteurs de virulence (métabolisme), Humains, Interférons (antagonistes et inhibiteurs), Lignée cellulaire, Protéines virales (génétique), Protéines virales (métabolisme), Signaux de localisation nucléaire, Similitude de séquences d'acides aminés, Séquence d'acides aminés, Virulence, Virus du SRAS (immunologie), Virus du SRAS (isolement et purification), Virus du SRAS (pathogénicité), Échappement immunitaire.
- MESH :
- antagonistes et inhibiteurs : Interférons.
- génétique : Facteurs de virulence, Protéines virales.
- immunologie : Virus du SRAS.
- isolement et purification : Virus du SRAS.
- métabolisme : Facteur-3 de régulation d'interféron, Facteurs de virulence, Protéines virales.
- pathogénicité : Virus du SRAS.
- virologie : Chiroptera.
- Animaux, Données de séquences moléculaires, Humains, Lignée cellulaire, Signaux de localisation nucléaire, Similitude de séquences d'acides aminés, Séquence d'acides aminés, Virulence, Échappement immunitaire.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Cell Line, Chiroptera (virology), Humans, Immune Evasion, Interferon Regulatory Factor-3 (metabolism), Interferons (antagonists & inhibitors), Molecular Sequence Data, Nuclear Localization Signals, SARS Virus (immunology), SARS Virus (isolation & purification), SARS Virus (pathogenicity), Sequence Homology, Amino Acid, Viral Proteins (genetics), Viral Proteins (metabolism), Virulence, Virulence Factors (genetics), Virulence Factors (metabolism).
- MESH :
- chemical , antagonists & inhibitors : Interferons.
- chemical , genetics : Viral Proteins, Virulence Factors.
- chemical , metabolism : Interferon Regulatory Factor-3, Viral Proteins, Virulence Factors.
- immunology : SARS Virus.
- isolation & purification : SARS Virus.
- pathogenicity : SARS Virus.
- virology : Chiroptera.
- Amino Acid Sequence, Animals, Cell Line, Humans, Immune Evasion, Molecular Sequence Data, Nuclear Localization Signals, Sequence Homology, Amino Acid, Virulence.
Abstract
The ORF3b protein of severe acute respiratory syndrome coronavirus (SARS-CoV) has a nuclear localization signal (NLS) at its C terminus and antagonizes interferon (IFN) function by modulating the activity of IFN regulatory factor 3 (IRF3). SARS-like coronaviruses (SL-CoVs) found in bats share an identical genome organization and high sequence identity for most of their gene products. In this study, ORF3b homologues were identified from three bat SL-CoV strains. These ORF3b homologues were C-terminally truncated and lacked the C-terminal NLS of SARS-CoV. IFN antagonist activities analysis demonstrated that one SL-CoV ORF3b still possessed IFN antagonist and IRF3-modulating activities. These results indicate that different ORF3b proteins display different IFN antagonist activities and this function is independent of the protein's nuclear localization, suggesting a potential link between bat SL-CoV ORF3b function and viral pathogenesis.
DOI: 10.1099/vir.0.033589-0
PubMed: 22012463
Affiliations:
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xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Cell Line</term><term>Chiroptera (virology)</term><term>Humans</term><term>Immune Evasion</term><term>Interferon Regulatory Factor-3 (metabolism)</term><term>Interferons (antagonists & inhibitors)</term><term>Molecular Sequence Data</term><term>Nuclear Localization Signals</term><term>SARS Virus (immunology)</term><term>SARS Virus (isolation & purification)</term><term>SARS Virus (pathogenicity)</term><term>Sequence Homology, Amino Acid</term><term>Viral Proteins (genetics)</term><term>Viral Proteins (metabolism)</term><term>Virulence</term><term>Virulence Factors (genetics)</term><term>Virulence Factors (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Chiroptera (virologie)</term><term>Données de séquences moléculaires</term><term>Facteur-3 de régulation d'interféron (métabolisme)</term><term>Facteurs de virulence (génétique)</term><term>Facteurs de virulence (métabolisme)</term><term>Humains</term><term>Interférons (antagonistes et inhibiteurs)</term><term>Lignée cellulaire</term><term>Protéines virales (génétique)</term><term>Protéines virales (métabolisme)</term><term>Signaux de localisation nucléaire</term><term>Similitude de séquences d'acides aminés</term><term>Séquence d'acides aminés</term><term>Virulence</term><term>Virus du SRAS (immunologie)</term><term>Virus du SRAS (isolement et purification)</term><term>Virus du SRAS (pathogénicité)</term><term>Échappement immunitaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Interferons</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Viral Proteins</term><term>Virulence Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Interferon Regulatory Factor-3</term><term>Viral Proteins</term><term>Virulence Factors</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Interférons</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteurs de virulence</term><term>Protéines virales</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteur-3 de régulation d'interféron</term><term>Facteurs de virulence</term><term>Protéines virales</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Chiroptera</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Chiroptera</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Cell Line</term><term>Humans</term><term>Immune Evasion</term><term>Molecular Sequence Data</term><term>Nuclear Localization Signals</term><term>Sequence Homology, Amino Acid</term><term>Virulence</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Données de séquences moléculaires</term><term>Humains</term><term>Lignée cellulaire</term><term>Signaux de localisation nucléaire</term><term>Similitude de séquences d'acides aminés</term><term>Séquence d'acides aminés</term><term>Virulence</term><term>Échappement immunitaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The ORF3b protein of severe acute respiratory syndrome coronavirus (SARS-CoV) has a nuclear localization signal (NLS) at its C terminus and antagonizes interferon (IFN) function by modulating the activity of IFN regulatory factor 3 (IRF3). SARS-like coronaviruses (SL-CoVs) found in bats share an identical genome organization and high sequence identity for most of their gene products. In this study, ORF3b homologues were identified from three bat SL-CoV strains. These ORF3b homologues were C-terminally truncated and lacked the C-terminal NLS of SARS-CoV. IFN antagonist activities analysis demonstrated that one SL-CoV ORF3b still possessed IFN antagonist and IRF3-modulating activities. These results indicate that different ORF3b proteins display different IFN antagonist activities and this function is independent of the protein's nuclear localization, suggesting a potential link between bat SL-CoV ORF3b function and viral pathogenesis.</div></front></TEI><affiliations><list><country><li>Australie</li><li>République populaire de Chine</li></country><region><li>Hubei</li></region><settlement><li>Wuhan</li></settlement></list><tree><country name="République populaire de Chine"><region name="Hubei"><name sortKey="Zhou, Peng" sort="Zhou, Peng" uniqKey="Zhou P" first="Peng" last="Zhou">Peng Zhou</name></region><name sortKey="Li, Hongxia" sort="Li, Hongxia" uniqKey="Li H" first="Hongxia" last="Li">Hongxia Li</name><name sortKey="Shi, Zhengli" sort="Shi, Zhengli" uniqKey="Shi Z" first="Zhengli" last="Shi">Zhengli Shi</name><name sortKey="Wang, Hanzhong" sort="Wang, Hanzhong" uniqKey="Wang H" first="Hanzhong" last="Wang">Hanzhong Wang</name></country><country name="Australie"><noRegion><name sortKey="Wang, Lin Fa" sort="Wang, Lin Fa" uniqKey="Wang L" first="Lin-Fa" last="Wang">Lin-Fa Wang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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